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Short Paper | Special issue | Vol 93, No. 2, 2016, pp.745-754
Published online, 5th February, 2016
DOI: 10.3987/COM-15-S(T)28
Continuous Flow Microfluidic Chemistry: Synthesis of [18F]-3-Fluoro-2-(4-((2-nitro-1H-Imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)Propan-1-ol, [18F]F-HX4, A Potent Hypoxia Agent

Murthy Akula, David Blevins, and George W. Kabalka*

*Chemistry Department, University of Tennessee, Knoxville, Tennessee, 37996-1600, U.S.A.


The microfluidic synthesis of the promising hypoxia imaging agent [18F]-3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol, [18F]F-HX4, was successfully accomplished using a commercial microfluidic system. A decay corrected radiochemical yield of 48±4% (n=4) and radiochemical purity of ≥ 98% was obtained. The total reaction time including the HPLC purification was 40 min.