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Paper | Special issue | Vol 93, No. 1, 2016, pp.185-201
Published online, 2nd November, 2015
DOI: 10.3987/COM-15-S(T)16
Diversity-Oriented Approach to 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives

Sambasivarao Kotha,* Shilpi Misra, Nimita Gopal Krishna, Vijayalakshmi Bandi, Mohammad Saifuddin, and Nagaraju Devunuri

*Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai - 400076, India


A convenient method is reported for synthesizing various 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives and bis-armed -amino acid derivatives by treating dibromo-o-xylylenes precursor with diethyl acetamidomalonate under basic conditions. Suzuki coupling reaction has been used to expand this methodology. One of the structure revision of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid into bis-armed amino acid is also reported.