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Short Paper | Special issue | Vol 93, No. 1, 2016, pp.378-390
Published online, 10th November, 2015
DOI: 10.3987/COM-15-S(T)15
A Short Synthesis of 2,3,5-Trisubstituted Pyrroles by an Alkylation/Dehydrocyanation Sequence

Murat Kucukdisli, Marco M. Nebe, Solveig M. Bartelt, and Till Opatz*

*Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany


2,3,5-Trisubstituted pyrroles were prepared in a one-pot procedure from readily available 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles by an alkylation/dehydrocyanation sequence. The method was also applied to α-dihaloalkanes to furnish dipyrroles tethered with an alkyl spacer.