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Short Paper | Regular issue | Vol 91, No. 9, 2015, pp.1781-1796
Published online, 6th August, 2015
DOI: 10.3987/COM-15-13267
■ Regioselective Synthesis of Pyrazoles and Pyrazolo[1,5-a]Pyrimidines: Structural Characterization by HMBC NMR

Abdullah S. Al-Bogami and Tamer S. Saleh*

*Department of Green Chemistry, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt

Abstract

In this study a series of novel pyrazoles and pyrazolo[1,5-a]pyrimidines with a sulfone moiety incorporated the coumarin ring were efficiently synthesized. These pyrazoles and pyrazolo[1,5-a]pyrimidines were synthesized by treating enaminone derivative of β-ketosulfone (3-(2-tosylacetyl)-2H-coumarin) with substituted hydrazines and 5-aminopyrazole derivatives, respectively under microwave irradiation. The structures of the products thus obtained were characterized by 2D NMR (HMBC).