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Short Paper | Special issue | Vol 93, No. 1, 2016, pp.362-377
Published online, 29th October, 2015
DOI: 10.3987/COM-15-S(T)13
Chemical Reactivity and Application of 4-Alkylidene-3H-pyrazol-3-ones: Synthesis and Antifungal Activity of Polysubstituted Pyrazoles

Hiroshi Maruoka,* Masataka Hokao, Nobuhiro Kashige, Eiichi Masumoto, Fumi Okabe, Reiko Tanaka, Fumio Miake, Toshihiro Fujioka, and Kenji Yamagata

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan


Chemical reactivity and application of 4-alkylidene-3H-pyrazol-3-ones are described. Furthermore, twelve of the newly synthesized O-substituted pyrazoles were evaluated for their antifungal activity in vitro against Candida albicans and Saccharomyces cerevisiae.