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Review | Regular issue | Vol 91, No. 8, 2015, pp.1555-1577
Published online, 14th July, 2015
DOI: 10.3987/REV-15-822
Synthesis and Bioactivity of Pyrroloindazoles: An Overview

Manas Chakrabarty,* Moumita Rakshit, and Gandhi K Kar

*Department of Chemistry, Presidency University, 86/1, College Street, Kolkata-700073, India


In this review, the synthesis and bioactivity of pyrroloindazoles have been presented. The pyrroloindazoles were synthesised either by the heteroannulation of tetrahydro-indolones/isoindolones, aminoindazoles, Sonogashira/Cacchi indazolic substrates or acyl/aroylindole ketoxime dinitrophenyl ethers or by the cycloaddition of indolynes, indazolic betaines, styrylpyrazoles and nitroindazoles. Several pyrroloindazoles showed analgesic, antiinflammatory and antitumor properties, inhibition of Pim kinase and soluble guanylate cyclase, and antagonism of NMDA-receptor.