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Paper | Special issue | Vol 93, No. 1, 2016, pp.333-346
Published online, 1st December, 2015
DOI: 10.3987/COM-15-S(T)55
Synthesis of 7,7′-Linked-bis-Indoles via 7-Tryptamines

Hakan Kandemir, Ibrahim F. Sengul, Christopher R. Gardner, Eryn L. Werry, Melissa L. Barron, Michael Kassiou, Naresh Kumar, and David StC. Black*

*School of Chemistry, The University of New South Wales, Sydney 2052, Australia


The synthesis of 7-tryptamines was accomplished via the reduction of 7-nitrovinylindoles which were developed by the condensation of indole-7-carbaldehydes with nitromethane and ammonium acetate. 7-Tryptamines were subsequently used for the construction of 2,3-disubstituted and 3-substituted 7,7-linked-bis-indoles.