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Short Paper | Special issue | Vol 93, No. 2, 2016, pp.802-815
Published online, 30th October, 2015
DOI: 10.3987/COM-15-S(T)53
Practical Synthesis of Tricyclic Lactam Model of Antitumor Renieramycin-Saframycin Natural Products

Masashi Yokoya, Akiya Fujino, Ayako Yaguchi, Miku Yamazaki, and Naoki Saito*

*Department of Medicinal Chemistry, Pharmaceutical Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

A practical synthesis of the tricyclic lactam model compound of antitumor renieramycin-saframycin natural product starting from 2-hydroxy-4,5-dimethoxy-3-methylbenzaldehyde in eleven steps was described. A tosyl group was used for protection of a phenol during this transformation. The overall yield of the target compound was 23%.