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Short Paper | Regular issue | Vol 91, No. 8, 2015, pp.1628-1636
Published online, 18th June, 2015
DOI: 10.3987/COM-15-13231
Synthesis of Phenylselanylisochroman-1-ones through Highly Selective Selenolactonization of Styrene-Typed Carboxylic Acids

Enshan Zhou,* Xin Han, Yuanyuan Li, Chao Guo, and Chune Dong*

*School of Pharmaceutical Sciences, Wuhan University, Hubei, Wuhan, 430071, China


The novel synthesis of phenylselanylisochroman-1-ones was achieved by selenolactonization of styrene-typed carboxylic acids and phenylselenenyl chloride in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO). The reactions give excellent yields with high exo-selectivity.