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Short Paper | Regular issue | Vol 91, No. 7, 2015, pp.1429-1438
Published online, 26th May, 2015
DOI: 10.3987/COM-15-13229
A New N-Glucosylated Indole Alkaloid and a New O-Serine Glycoside from Berberis koreana

Ki Hyun Kim, Hee Rae Kang, Eunjung Moon, Sang Un Choi, Ki Sung Kang, Sun Yeou Kim, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Korea

Abstract

A new N-glucosylated indole alkaloid, 1-(1-β-glucopyranosyl)-3-(hydroxymethyl)-1H-indole (1) and a new O-serine glycoside, 3-O-α-D-xylopyranosyl-L-serine methyl ester (2), along with five known compounds (3-7) were isolated from the trunk of Berberis koreana. The structures of the new compounds were elucidated by 1D and 2D NMR data analysis and chemical reaction. Compounds 1, 2, 4, 5, and 7 reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line. In addition, compounds 4 and 5 showed moderate anti-proliferative activity against A549 and HCT-15 cell lines.