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Communication | Regular issue | Vol 91, No. 6, 2015, pp.1164-1169
Published online, 26th May, 2015
DOI: 10.3987/COM-15-13223
A New Strategy for Synthesis of the Dinucleotide pdCpA: A Convenient Method for the Deprotection of Cyanoethyl, TBDMS, and Benzoyl Groups in One Step at High Pressure

Masanori Kataoka,* Chiharu Fukui, Akiko Mimoto, Hideaki Kuge, Koichi Honke, and Hiyoshizo Kotsuki*

*Laboratory of Natural Products Chemistry, Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan

Abstract

A new improved method for the preparative-scale synthesis of the dinucleotide pdCpA was developed. This method takes advantage of the complete deprotection of cyanoethyl, TBDMS, and benzoyl groups in one step under high-pressure conditions in the final stage of the synthetic sequence.