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Short Paper | Regular issue | Vol 91, No. 6, 2015, pp.1212-1226
Published online, 11th May, 2015
DOI: 10.3987/COM-15-13209
Synthesis and Cytotoxicity Activity of Some Novel Hydrazide, Pyrazole, Isoxazole, Pyrimidine and Fused Pyran-2-one Derivatives

Hala M. Refat* and Ahmed A. Fadda

*Faculty of Science, Department of Chemistry, Suez Canal University, Al-Arish, 45511, Egypt


The reaction of 2-cyano-3-(dimethylamino)-N-((2-methoxynaphthalen-1-yl)methylene)acrylohydrazide (2) with some nitrogen nucleophiles, phenols and compounds, having an active methylene group to synthesis polyfunctionally substituted azoles (3-5), azine (6), fused azines (7-10) and fused pyran-2-one (11-17) derivatives. All the synthesized products were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and MS data. The antitumor evaluation of the newly products against the four human tumor cells lines namely heptacelluar carcinoma (liver) HepG-2, Colorectal carcinoma (colon) HCT-116, mammary gland (breast) MCF-7 and Epdermoid carcinoma (larynx) Hep-2 was investigated. Compound 4 exhibited superior in vitro antitumor activity in the 3-cell lines assay.