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Short Paper | Regular issue | Vol 91, No. 8, 2015, pp.1615-1627
Published online, 29th June, 2015
DOI: 10.3987/COM-15-13222
Novel Grinding Synthesis of Pyranopyrazole Analogues and Their Evaluation as Antimicrobial Agents

Ashok Sharma, Badvel Pallavi, Rajnish Prakash Singh, Prabhat Nath Jha, and Paritosh Shukla*

*Department of Chemistry, Birla Institute of Technology and Science, BITS-Pilani, Pilani-333301, Rajasthan, 333031, India


The paper describes the results of a new four-component synthesis of pyranopyrazole heterocycles by solvent-free one-pot grinding of malononitrile, hydrazine, ethyl acetoacetate, and various aldehydes in the presence of a base. The reaction proceeded smoothly at room temperature with good yields in very short reaction time. The synthesised compounds were evaluated for their in-vitro antibacterial activity against three different bacterial and three different fungal strains. The highlight of this work is that the synthesis was activity-driven. The brief SAR correlation found that the tested compounds showed better activity against fungal strains.