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Short Paper | Regular issue | Vol 91, No. 3, 2015, pp.610-625
Published online, 5th February, 2015
DOI: 10.3987/COM-15-13169
Synthesis and Reactivity of Cyanomethyl Thiazolyl Ketone: A Facile Synthesis of Some New Azoles, Chromene, Pyridine, Thiophene, Pyrazolo[3,4-b]pyridine and Pyrimido[1,2-a]benzimidazole Derivatives

Mohamed Abdelmonem Raslan, Mohamed A. Khalil, and Samia M. Sayed*

*Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt


Several new heterocyclic compounds such as chromene, pyrazole, isoxazole, dihydropyridine, thiazole, thiophene, pyrazolopyridine and pyrimidobenzimidazole derivatives have been synthesized by the reactions of the versatile multifunctional unreported 3-(4-methyl-2-(tosylamino)thiazol-5-yl)-3-oxopropanenitrile with several nitrogen binucleophiles. A one-pot three component reaction of an aldehyde, the 3-oxopropanenitrile derivative, and electron-rich heterocyclic amines has been decribed.