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Paper | Regular issue | Vol 91, No. 4, 2015, pp.719-725
Published online, 3rd March, 2015
DOI: 10.3987/COM-14-13164
An Cost-Effective and Safe Process of L-cis-4,5-Methanoproline Amide, the Key Synthetic Intermediate of Saxagliptin, via an Improved Simmons-Smith Reaction

Ding ding, Xianhua Pan, Wansheng Yu, Xiaojun Li, Suke Chen, and Feng Liu*

*School of Perfume and Aroma Technology, Shanghai Institute of Technology, Haiquan Rd. 100 Shanghai, 201418, China


L-cis-4,5-Methanoproline amide, a key intermediate of saxagliptin, was synthesized by an improved Simmons-Smith reaction. The zinc carbenoid was formed through Zn/CuBr and CH2I2, under the optimized condition, the title compound was gained with 68% yield and excellent diastereomeric selectivity (40:1 d.r.). The absence of the flammable and expensive ZnEt2 makes this procedure very attractive in large scale production.