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Paper | Regular issue | Vol 91, No. 3, 2015, pp.505-514
Published online, 5th February, 2015
DOI: 10.3987/COM-14-13149
Structures and Bioactivities of Xenicanes from an Okinawan Soft Coral Xenia sp.

Wilmar Maarisit, Kentaro Yano, Tomofumi Miyazato, Prodip K. Roy, Junsei Taira, and Katsuhiro Ueda*

*Department of Chemistry, Biology and Marine Sciences, Faculty of Science, University of Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-0213, Japan

Abstract

Three new xenicane diterpenoids 13 were isolated from a soft coral Xenia sp. together with the known xenicanes 47. Their structures were determined by spectroscopic methods and the structure of 1 was further confirmed by single X-ray diffraction analysis. Metabolites 17 showed weak cytotoxicity against HCT 116 cells and a dose dependent, anti-inflammatory effect in LPS/IFN-γ-stimulated inflammatory RAW 264.7 macrophage cells.