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Paper | Regular issue | Vol 91, No. 2, 2015, pp.287-300
Published online, 19th January, 2015
DOI: 10.3987/COM-14-13137
Synthesis of Some New Isoindoline-1,3-dione Based Heterocycles

Islam H. El Azab* and Mohamed R. E. Aly

*Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt


2-(4-((4-Oxothiazolidin-2-ylidene)amino)-1-phenyl-1H-pyrazole-3-carbonyl)-isoindoline-1,3-dione 7 was prepared as new threepharmacophoricmotif key intermediate. Compound 7 was incorporated in a series of manipulations including cyclocondensation reactions to afford a series of fourpharmacophoricmotif conjugates 9, 11, 12, 15, 16, 19 and 21 in good yields. The newly synthesized compounds were characterized by IR, NMR, MS and elemental analyses.