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Short Paper | Regular issue | Vol 91, No. 2, 2015, pp.381-387
Published online, 7th January, 2015
DOI: 10.3987/COM-14-13136
Xanthones from the Fermentation Products of an Endophytic Fungus Phomopsis sp.

Lin Yuan,1 Wenzhong Huang,1 Kun Zhou,2 Yuede Wang,2 Wei Dong,2 Jie Lou,2 Limei Li,2 Gang Du,2 Haiying Yang,2 Yinhai Ma,1,* and Qiufen Hu2,*

*1 Chemical Science and Technology Department, Kunming University, Kunming 650214, P. R. China; 2 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, P. R. China

Abstract

Three new xanthones, dalienxanthones A-C (1-3), together with three known analogues (4-6), were isolated from the fermentation products of an endophytic fungus Phomopsis sp. cultivated on Paris daliensis. Their structures were identified by extensive spectroscopic techniques, especially 2D-NMR. The cytotoxicity activities of all compounds were evaluated against five cancer cell lines including NB4, A549, SHSY5Y, PC3, and MCF-7. Compounds 3 and 4 showed cytotoxicities against SHSY5Y cells with IC50 values of 3.8 and 3.5 μM, respectively. The other compounds also showed cytotoxicity for some tested cell lines with IC50 values between 4.6 - 9.2 μM.