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Short Paper | Regular issue | Vol 91, No. 1, 2015, pp.123-133
Published online, 19th December, 2014
DOI: 10.3987/COM-14-13123
Three-Component Synthesis of New Substituted Bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole] Derivatives and Evaluation of Their Antibacterial Activity

Jafar Abbasi Shiran, Asieh Yahyazadeh,* Bohari M. Yamin, Manouchehr Mamaghani, and Hamzeh Kiyani

*Department of Chemistry, College of Science, University of Guilan, Rasht 41335, Iran


Several new derivatives of 2,2'-(4,4'-ethylenebiphenyl)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole], 2,2'-(4,4'-biphenylsolfone)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole], 2,2'-(4,4'-methylene¬biphenyl)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole] and 2,2'-(1,4-phenylene)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole] derivatives were synthesized by the condensation reaction of various isothiocyanates, diamines, and phenacyl bromide. The one-pot, three-component synthesis of new containing-iminothiazole heterocycles conducted using catalytic amounts of triethylamine. Furthermore, the target compound 8b was further determined by X-ray crystallographic analysis. The antimicrobial activity of the synthesized compounds was evaluated against Salmonella enterica, Micrococcus luteus, Bacillus subtilis and Pseudomonas aeruginosa.