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Review | Regular issue | Vol 91, No. 4, 2015, pp.701-717
Published online, 17th February, 2015
DOI: 10.3987/REV-14-812
■ Chemistry of Macrocyclic β-Lactam: An Overveiw

Vijaya Bhaskar Vangala, Mahagundappa Rachappa Maddani, Rama Mohan Hindupur, and Hari Narayan Pati*

*Department of Chemistry, Advinus Therapeutics Ltd., 21 and 22 Peenya Industrial Area, 560058, India

Abstract

β-Lactam macrocycles displayed major contributions in the filed of drug discovery. The chemical potentiality of β-lactam has proved their usefulness in the discovery of variety of conformationally restricted macrocycles. Macrocycles containing versatile functionalities derived from β-lactam have also been employed in the fields of supramolecular chemistry. In this review, attempts were made to summarize the recent methods for synthesis of potential β-lactam containing macrocycles.