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Short Paper | Regular issue | Vol 89, No. 12, 2014, pp.2794-2805
Published online, 12th December, 2014
DOI: 10.3987/COM-14-13112
Synthesis and Evaluation of Selenoflavones That Have Potential Neuroprotective Effects

Yong-Sung Choi, Yoon-Jung Kim, Ju Yeun Lee, Jinu Lee, and Jin-Hyun Jeong*

*College of Pharmacy, Yonsei University, 162-1 Songdodong, Yeonsugu, Incheon, Korea

Abstract

We synthesized selenoflavones and evaluated their physicochemical properties and antioxidant effects. When oxygen was substituted with selenium, the compounds exhibited improved polarity and lipophilicity, implying that this change could lead to better BBB penetration. Selenoflavones revealed more potent antioxidant activity in our in-vitro assay. This suggests that selenoflavones would be more druggable than flavones and have a better potential as a neuroprotective agent.