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Short Paper | Regular issue | Vol 89, No. 12, 2014, pp.2777-2785
Published online, 12th December, 2014
DOI: 10.3987/COM-14-13110
One-Pot Synthesis of New Benzimidazole Derivatives Promoted by Potassium Carbonate

Meng-Wei Xue, Hong Zhou, Jing-Jing Yang, Jian Li, Shao-Xian Liu, and Dun-Lin Zhang*

*School of Bio-Chemistry and Environmental Engineering, Nanjing Xiaozhuang University, 3601 Hongjing Road, Jiangning District, Nanjing 211171, China


An efficient method for synthesis of new benzoimidazoline derivatives has been accomplished via a one-pot reaction of aromatic aldehyde, o-phenylenediamine / 4-Cl-o-phenylenediamine and acetic anhydride promoted by K2CO3. In this method, although aryl substituted aldehydes with electron-releasing substituents did not work in the reaction, a series of aryl substituted aldehydes carrying electron-withdrawing substituents gave the corresponding benzoimidazoline derivatives with good yields of 62 % - 93 %.