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Paper | Regular issue | Vol 89, No. 11, 2014, pp.2545-2553
Published online, 8th October, 2014
DOI: 10.3987/COM-14-13077
The Reaction of 2-((Trimethylsilyl)methyl)-2H-tetrazoles with Aldehydes and Ketones in the Presence of 1,8-Diazabicyclo[5.4.0]undec-7-ene

Hideaki Umemoto,* Takuya Onaka, Yasuyoshi Miki, Akira Nakamura, and Tomohiro Maegawa*

*Business Development Department, FUJIMOTO CHEMICALS Co., Ltd., 1-2-38 Kinrakuji-cho, Amagasaki, Japan


2-((Trimethylsilyl)methyl)-2H-tetrazoles were treated with aldehydes and ketones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 2-(2-hydroxyethyl)-2H-tetrazoles. This simple procedure offers a valuable strategy for the preparation of 2-(hydroxyethyl)-2H-tetrazoles.