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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Short Paper | Regular issue | Vol 89, No. 10, 2014, pp.2375-2379
Published online, 3rd October, 2014
Published online, 3rd October, 2014
DOI: 10.3987/COM-14-13069
■ Cytotoxicity Flavones from Desmodium oxyphyllum
Xue-Mei Gao, Huang Wang, Yin-Ke Li, Bing-Kun Ji, Cong-Fang Xia, Juan-Xia Yang, Ming Zhou, Yan-Qing Ye, and Qiu-Fen Hu*
*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China
Abstract
Two new flavones, oxyphyllumflavone A and B (1 and 2) were isolated from Desmodium oxyphyllum. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1 and 2 are the first naturally occurring flavones possessing a six-membered 6-methyl-α-pyrone ring. Compounds 1 and 2 were also evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 cell lines, and they showed cytotoxicity with IC50 values in the range of 4.2 – 9.6 μM.
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