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Short Paper | Regular issue | Vol 89, No. 7, 2014, pp.1662-1669
Published online, 28th May, 2014
DOI: 10.3987/COM-14-13004
Speradines B-E, Four Novel Tetracyclic Oxindole Alkaloids from the Marine-Derived Fungus Aspergillus oryzae

Xiao Hu, Qi-Wen Xia, Yang-Yang Zhao, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen,* and Qi-Qing Zhang*

*College of Chemistry and Chemical Engineering, Institute of Biomedical and Pharmaceutical Technology , Fuzhou University, No. 523, Gongye Road, Fuzhou City, 350002, China

Abstract

Four novel tetracyclic oxindole alkaloids, namely, speradines B (1), C (2), D (3), and E (4) were isolated from the marine-derived fungus Aspergillus oryzae. The structures of these compounds were elucidated through 1D and 2D nuclear magnetic resonance and high-resolution mass spectrometric analyses. Among these compounds, 1 and 4 showed weak cytotoxic effects on the hela cell line, with IC50 values of 57.2 and 73.4 μg/mL, respectively.