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Paper | Special issue | Vol 90, No. 1, 2015, pp.579-599
Published online, 24th July, 2014
DOI: 10.3987/COM-14-S(K)66
Studies toward the Total Synthesis of Amphidinolide N: Stereocontrolled Synthesis of the C13–C29 Segment

Makoto Sasaki,* Yuki Kawashima, and Haruhiko Fuwa

*Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan


A stereocontrolled synthesis of the C13–C29 segment of amphidinolide N, a marine macrolide natural product that is extremely potent cytotoxic, is described.