Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 90, No. 2, 2015, pp.928-938
Published online, 25th August, 2014
DOI: 10.3987/COM-14-S(K)52
Preparation of (2R,4S)/(2S,4S)-4-Hydroxypipecolinic Acid Derivatives from L-(–)-Malic Acid

Shuqiang Yin, Hiroshi Taneda, Bozhi Li, Dejun Zhou, Daishiro Minato, Kenji Sugimoto, and Yuji Matsuya*

*Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan


Synthetically important 4-hydroxypipecolinic acid derivatives were efficiently prepared from commercially available L-(–)-malic acid. The stereochemistries of the derivatives synthesized by our method were determined by coupling constant analyses with key methine protons on C2 and C4.