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Short Paper | Special issue | Vol 90, No. 1, 2015, pp.625-630
Published online, 2nd April, 2014
DOI: 10.3987/COM-14-S(K)12
Synthesis of Unprotected CH2-Skipped Piperazine-Pyridine Alternating Cycles with Azide End-Group

Andi Kipper, Indrek Kalvet, Kaido Tämm, Lauri Sikk, Peeter Burk, Kuldar Kõiv, and Uno Mäeorg*

*Institute of Chemistry, University of Tartu, Ravila 14a, Tartu 50411, Estonia


This work describes synthesis of CH2-skipped alternating piperazine-pyridine cycles with azide end-group starting from piperazine, 1-methylpiperazine and pyridine-2,6-dicarboxylic acid. This compound can be used to enhance binding efficiency by shielding repulsion between negatively charged phosphate groups in DNA-oligonucleotide hybridization techniques.