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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Short Paper | Regular issue | Vol 89, No. 5, 2014, pp.1221-1227
Published online, 2nd April, 2014
Published online, 2nd April, 2014
DOI: 10.3987/COM-14-12965
■ One-Pot Three-Component Synthesis of 3,5-Disubstituted Isoxazoles by a Coupling–Cyclocondensation Sequence
Hai-Ling Liu,* Zhu-Feng Geng, Si-Yu Zhang, and Jie Han
*Analytical & Testing Center, Beijing Normal University, No. 19, XinJieKouWai St., HaiDian District 100875, China
Abstract
A convenient one-pot procedure for the synthesis of 3,5-disubstituted isoxazoles from acid chloride, terminal alkyne, and hydroxylamine hydrochloride catalyzed by Pd(PPh3)2Cl2/CuI has been developed. The coupling of acid chlorides to terminal alkynes afforded α,β-unsaturated ynones that underwent in situ cyclocondensation with hydroxylamines to afford the desired isoxazoles in 44–76% isolated yields.
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