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Communication | Special issue | Vol 90, No. 1, 2015, pp.113-120
Published online, 19th August, 2014
DOI: 10.3987/COM-14-S(K)27
Facile Synthesis of Guaiazulene-Heterocycle Hybrids via Ugi Multicomponent Reactions

Naoko Takenaga,* Koh Fukazawa, Miki Maruko, and Koichi Sato*

*Laboratory of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan


The Ugi reaction with isocyanoazulene 1 afforded a variety of azulene-heterocycle hybrids. The described approach could be applied to combinatorial synthesis of biologically active compounds of the azulene series.