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Communication | Special issue | Vol 90, No. 2, 2015, pp.857-865
Published online, 3rd September, 2014
DOI: 10.3987/COM-14-S(K)79
Simple, Selective, and Practical Synthesis of 2-Substituted 4(3H)-Quinazolinones by Yb(OTf)3-Catalyzed Condensation of 2-Aminobenzamide with Carboxamides

Tsutomu Yoshimura, Di Yuanjun, Yu Kimura, Hisatsugu Yamada, Akio Toshimitsu, and Teruyuki Kondo*

*Advanced Biomedical Engineering Research Unit, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan


A simple, selective, and practical synthetic method of 4(3H)-quinazolinones is realized by Yb(OTf)3-catalyzed condensation of 2-aminobenzamide with carboxamides. As the reaction proceeds, NH3 and H2O were formed as byproducts; however, Yb(OTf)3 can operate as an efficient Lewis acid catalyst without deactivation.