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Short Paper | Regular issue | Vol 94, No. 10, 2017, pp.1885-1894
Published online, 8th September, 2017
DOI: 10.3987/COM-14-12951
Efficient Synthesis of Seven-Membered Cyclic Ethers Using Pd(II) Catalyst

Masahiro Miyazawa,* Yusuke Yano, Chiaki Hayashi, Masatake Okuno, Kenta Hara, Yoshiro Hirai, and Hajime Yokoyama

*Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Gofuku 3190, Toyama 930-8555, Japan

Abstract

We report a palladium(II)-catalyzed intramolecular cyclization of oct-2-ene-1,8-diol derivatives to afford seven-membered cyclic ethers without the need for high dilution and without dimer formation.