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Short Paper | Regular issue | Vol 89, No. 3, 2014, pp.753-761
Published online, 30th January, 2014
DOI: 10.3987/COM-14-12940
Simple and Efficient Synthesis of Phosphorylated Thienopyridones from 2-Aminothiophene-3-carboxylates and β-Phosphonylketones

Khaoula Khalladi and Soufiane Touil*

*Department of Chemistry, Faculty of Sciences of Bizerta, 7021-Jarzouna, Tunisia


Herein, we report an efficient and straightforward synthesis of the new 5-phosphonothieno[2,3-b]pyridin-4(5H)-ones, via the p-toluenesulfonic acid catalyzed reaction of ethyl 2-aminothiophene-3-carboxylates with β-phosphonylketones. To the best of our knowledge, this is the first synthesis of thienopyridone derivatives bearing a phosphonate or a phosphine oxide group.