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Paper | Regular issue | Vol 89, No. 3, 2014, pp.693-708
Published online, 6th February, 2014
DOI: 10.3987/COM-14-12939
Facile Synthesis of 2-Phenylquinoline-4-carboxamide Derivatives with Variant Structural Features

Rafiqul Islam, Md. Imran Hossain, Yoshinari Okamoto, Tomohisa Nagamatsu, Kensaku Anraku, and Tadashi Okawara*

*Medical Technology, Faculty of Health Science, Kumamoto Health Science University, 325 Izumimachi Kumamoto 881-5598, Japan


The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4-carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidinamine, 4,4'-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.