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Short Paper | Regular issue | Vol 89, No. 2, 2014, pp.495-502
Published online, 20th December, 2013
DOI: 10.3987/COM-13-12901
Synthesis of 6-Aryl-6,7-dihydro-8H-thiopyrano[2,3-b]pyrazin-8-ones by the Reaction of 3-Aryl-1-(3-chloropyrazin-2-yl)prop-2-en-1-ones with Sodium Hydrogensulfide

Kazuhiro Kobayashi* and Ayumi Imaoka

*Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan


A convenient process for the preparation of 6-aryl-6,7-dihydro-8H-thiopyrano[2,3-b]pyrazin-8-ones has been developed, which employs the reaction of 3-aryl-1-(3-chloropyrazin-2-yl)prop-2-en-1-ones, derived from 2- chloropyrazine and 3-arylprop-2-enals, with NaSH in DMF at –20 °C.