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Short Paper | Regular issue | Vol 89, No. 1, 2014, pp.183-188
Published online, 10th December, 2013
DOI: 10.3987/COM-13-12870
Chromone Derivatives from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

Guangyu Yang, Wei Zhao, Tao Zhang, Yuanxing Duan, Zhihua Liu, Mingming Miao, and Yongkuan Chen*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, China


Two new chromone derivatives, 5-hydroxy-9-methyl-1-(2-oxopropyl)benzo[β]oxepin-7(2H)-one (1), 5-hydroxy-2-methoxy-9-methyl-1-(2-oxopropyl)benzo[β]oxepin-7(2H)-one (2), together with five known chromone derivatives (3-7), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-7 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 showed high anti-TMV activity with inhibition rate of 31.5%. It inhibition rate is high than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 11.2 – 23.5%, respectively.