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Paper | Regular issue | Vol 89, No. 1, 2014, pp.103-112
Published online, 10th December, 2013
DOI: 10.3987/COM-13-12867
One-Pot Synthesis of 3,5-Diphenyl-1H-pyrazoles from Chalcones and Hydrazine under Mechanochemical Ball Milling

Ze Zhang,* Ya-Jun Tan, Chun-Shan Wang, and Hao-Hao Wu

*School of Biological & Chemical Engineering, Anhyui Polytechnic University, No. 8, Beijing Road, Wuhu 241000, China


A highly efficient and environmentally friendly method has been developed for facile synthesis of 3,5-diphenyl-1H-pyrazoles under mechanochemical ball-milling conditions. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap sodium persulfate as the oxidant, together with very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.