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Short Paper | Regular issue | Vol 87, No. 11, 2013, pp.2385-2394
Published online, 16th October, 2013
DOI: 10.3987/COM-13-12825
Design and Synthesis of New Hybrid Triazine-Indole Derivatives as Potential Antimicrobial Agents against Hospital Resistant Strains

Raed Al-Qawasmeh,* Monther A. Khanfar, Mohamad H. Semreen, Raed Abu Odeh, and Taleb H. Al-Tel

*Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan


A new series of antimicrobial [2-(5,6-diaryl-1,2,4-triazin-3-yl)-1H-indole] have been synthesized via microwave technology. The synthesized compounds were found to be potent against various clinical isolates of Gram-positive and Gram-negative bacteria as well as hospital resistant strains, MRSA and MSSA when compared to the drugs Cephtriaxone, Gentamycin and Levofloxacin.