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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Paper | Regular issue | Vol 87, No. 11, 2013, pp.2267-2281
Published online, 3rd October, 2013
Published online, 3rd October, 2013
DOI: 10.3987/COM-13-12812
■ Synthesis of Tetrasubstituted Pyrrolidine Derivatives Employing β-Lactam as a Chiral Building Block
Genta Tadano, Koji Ishikura, and Keiji Tanino*
*Department of Chemistry, Graduate School of Science, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810, Japan
Abstract
A new method for constructing tetrasubstituted pyrrolidine derivatives using the known β-lactam as a chiral building block was developed. After construction of a carbapenem skeleton, the β-lactam moiety was cleaved to afford a multi-substituted pyrrolidine. The present method was employed for the synthesis of A-315675 analogs 1 and 2.
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