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Short Paper | Regular issue | Vol 87, No. 11, 2013, pp.2319-2332
Published online, 15th October, 2013
DOI: 10.3987/COM-13-12810
Hydrazones and 1,3-Thiazolidin-4-ones Incorporating Furoxan Moiety Synthesized from Eugenol, the Main Constituent of Ocimum sanctum L. Oil

Nguyen Huu Dinh,* Trinh Thi Huan, Hoang Thi Tuyet Lan, and Sang-Bae Han

*Department of Chemistry, Hanoi National University of Education, 136 Xuanthuy Hanoi, Vietnam


Two series of new hydrazones and 1,3-thiazolidin-4-ones incorporating furoxan moiety were synthesized from eugenol, the main component of Ocimum sanctum L. oil. The structure of these compounds was determined by IR, MS, 1H and 13C NMR analysis. All resonance signals of proton and carbon in the examined compounds are assigned using HSQC, HMBC and NOESY spectra. The hydrazones and the 1,3-thiazolidin-4-ones were tested for antimicrobial activities and almost all examined thiazolidinones displayed moderate activity against S. aureus and A. niger. Among screened hydrazones only one compound exhibited a significant cytotoxicity for human cancer cell line SW620.