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Review | Regular issue | Vol 91, No. 6, 2015, pp.1137-1155
Published online, 10th April, 2015
DOI: 10.3987/REV-14-809
Recent Progress in The Synthetic Study of an Antitumor Marine Macrolide Aplyronine A and Related Molecules

Ichiro Hayakawa* and Hideo Kigoshi*

*Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki 305-8571, Japan


Aplyronine A is a potent antitumor marine macrolide. The unique molecular structures of aplyronine A and its congeners, in conjunction with their potent biological activities, have made them attractive synthetic targets. This review discusses recent progress in the development of efficient routes to the synthesis of aplyronines and the related molecules.