HETEROCYCLES

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■ SYNTHESIS OF 3,7,9- AND 2,6,9-TRIAZABICYCLO[3.3.1]NONANE DERIVATIVES

Ambara R. Pradipta and Katsunori Tanaka*

*Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

Due to their interesting chemical and biological properties, nitrogen containing-heterocycles represent indispensable moiety in organic chemistry. From the various types of nitrogen containing-heterocycles, azabicyclic compounds in particular are of considerable importance in many aspects and have attracted attention from wide range of fields, including in the study of natural products, coordination properties, or in the development of biologically and pharmacologically active compounds. This review focuses on the hitherto reported methods for the synthesis of the triazabicyclo[3.3.1]nonane derivatives, the bicyclic compound having two nitrogen atoms at the eight-membered ring and one nitrogen atom at the bridge position, which are less explored in the literature probably due to difficulties in their synthetic accessibility.