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Paper | Special issue | Vol 88, No. 1, 2014, pp.535-546
Published online, 5th August, 2013
DOI: 10.3987/COM-13-S(S)77
Potential DNA Bis-Intercalating Agents. Synthesis and Antitumor Activity of N,N'-(Methylenedi-4,1-cyclohexanediyl-bis(9-acridinamine) Isomers

Gordon W. Gribble,* Michael D. Mosher, Gary D. Jaycox, Michael Cory, and Terri A. Fairley

*6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, U.S.A.

Abstract

We describe the synthesis and antitumor activity of three novel isomeric bis-acridines 14-16 possessing a non-aromatic, semi-rigid dicyclohexylmethylene tether.