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Short Paper | Regular issue | Vol 87, No. 8, 2013, pp.1711-1726
Published online, 10th June, 2013
DOI: 10.3987/COM-13-12730
Synthesis of Novel Coumarin Derivatives and in vitro Biological Evaluation as Potential PTP 1B Inhibitors

Cheng Sun, Chune Peng, Jian Wang, Quan Wang, Wei Liu, Honggang Zhou,* and Cheng Yang

*College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China


The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 μM, which would be considered for further study.