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Paper | Regular issue | Vol 87, No. 6, 2013, pp.1279-1287
Published online, 10th May, 2013
DOI: 10.3987/COM-13-12720
Synthesis of 5-Amino or 4-Amino Substituted 7-Aza-isoindolin-1-ones

Heng Zhou, Qunfeng Shi, Xiangchao Liu, Xiaoping Zhan, Zenglu Liu, and Zhenmin Mao*

*School of Pharmacy, Shanghai Jiaotong University , No.800 Dongchuan Road, Minhang District, Shanghai 200240, China


A simple and convenient route for the synthesis of a series of 5-amino or 4-amino substituted 7-aza-isoindolin-1-ones is described. Amino substituted pyridine derivatives were cyclized with different amines in alkaline condition to give the desired products.