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Short Paper | Special issue | Vol 88, No. 1, 2014, pp.603-606
Published online, 11th June, 2013
DOI: 10.3987/COM-13-S(S)7
Lewis Acid-Catalyzed Formylation Reaction of 4-(Piperazin-1-yl)phenols

Giuseppe Cremonesi, Piero Dalla Croce,* and Concetta La Rosa

*DISFARM - Section of General and Organic Chemistry "A. Marchesini", University of Milano, Via Venezian 21, I-20133 Milano, Italy

Abstract

The Lewis acid-catalyzed reaction of phenols 1 with paraformaldehyde in aprotic solvents affords good yields of salicylaldehydes 2.