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■ Promoting Effects on Hepatocyte Growth Factor Production of Daphnane Diterpenoids from Daphne odora

Rie Nakasone, Manami Kurisu, Manami Onodera, Yusaku Miyamae, Daisuke Matsuura, Hirotoshi Kanatani, Shingo Yano, and Hideyuki Shigemori*

*Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Japan

Abstract

Five daphnane diterpenoids, gnidilatidin (1), gnidilatidin 20-palmitate (2), yuanhuajine (3), odoratrin (4), and synaptolepis factor K4 (5), isolated from Daphne odora were used to evaluate the promoting effect on hepatocyte growth factor (HGF) production in normal human dermal fibroblasts (NHDF). All the tested compounds except for 2 increased the amount of HGF production significantly. According to the structure-activity relationships of compounds 1-5 and the derivative 6, it was revealed that a hydroxy group at C-20 was essential for expression of HGF production promoting activity.