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Review | Special issue | Vol 88, No. 1, 2014, pp.75-101
Published online, 11th July, 2013
DOI: 10.3987/REV-13-SR(S)1
Synthesis of Heterocycles via Nucleophilic Substitution of Hydrogen in Nitroarenes

Mieczysław Mąkosza* and Krzysztof Wojciechowski

*Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, P.O.Box 58, PL-01-224 Warszawa 42, Poland


The main message of this review is that nucleophilic substitution of hydrogen in nitroarenes and other electron-deficient arenes is primary general process of wide scope and great value in organic synthesis, whereas conventional nucleophilic substitution of halogens, SNAr reaction, is just a secondary process. Nucleophilic substitution of hydrogen in electron-deficient arenes is a powerful tool in organic synthesis, effectively applicable to the synthesis of heteroaromatic compounds.