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Review | Special issue | Vol 88, No. 1, 2014, pp.103-127
Published online, 16th July, 2013
DOI: 10.3987/REV-13-SR(S)2
Additive Effects on Asymmetric Hydrogenation of N-Heteroaromatics

Takuto Nagano, Atsuhiro Iimuro, Kenta Yamaji, Yusuke Kita, and Kazushi Mashima*

*Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan


The multiplication of chiral information is one of the most important tasks in organic chemistry. Chiral catalysis is the most elegant way to achieve this and organic chemists developed a variety of catalytic asymmetric reaction systems, in which the addition of some chemicals effectively improves the performance of transition-metal-catalysis. In this review, we summarize development of additive effects in the asymmetric hydrogenation of N-heteroaromatic compounds based on interactions of additives with catalysts and substrates.