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Short Paper | Special issue | Vol 88, No. 1, 2014, pp.591-594
Published online, 18th April, 2013
DOI: 10.3987/COM-13-S(S)3
Aaptoline A, a New Quinoline Alkaloid from the Marine Sponge Aaptos suberitoides

Yodai Kudo, Hikaru Kato, Henki Rotinsulu, Fitje Losung, Remy E. P. Mangindaan, Nicole J. de Voogd, and Sachiko Tsukamoto*

*Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


A new quinoline alkaloid, aaptoline A (1), was isolated from the marine sponge Aaptos suberitoides, along with known alkaloids, aaptamine (2), isoaaptamine (3), and demethylaaptamine (4). Interestingly, 1-4 are presumably biosynthesized from common precursors, L-DOPA and β-alanine aldehyde.